Antihyperlipidemic Drugs. c h a p t e r atherosclerosis bile acid sequestrants catalyst cholesterol high-density lipoproteins (HDL). HMG-CoA. Hypolipidemic agents, or antihyperlipidemic agents, are a diverse group of pharmaceuticals that are used in the treatment of high levels of fats (lipids), such as cholesterol, in the blood (hyperlipidemia). They are called lipid-lowering drugs . Contents. 1 Classes. Established. 2 Research; 3 References; 4 See also. Chapter 18 Antihyperlipidemic Agents LEARNING OBJECTIVES Define hyperlipidemia and atherosclerosis, and their causes Classify antihyperlipidemics.
|Published (Last):||2 June 2013|
|PDF File Size:||14.34 Mb|
|ePub File Size:||3.77 Mb|
|Price:||Free* [*Free Regsitration Required]|
In addition, it is the most potent antihyperlipidemic agent for raising plasma HDL levels, which is the most common indication for its clinical use.
Antihyprrlipidemic marine triglycerides Maxepa contain the triglyceride precursors of two polyunsaturated fatty acids derived from oily fish. Stay ahead with the world’s most comprehensive technology and business learning platform.
Nausea and abdominal pain. Upload from Desktop Single File Upload.
As a regulator of homeostasis, a precursor to the corticosteroids and sex hormones, and a critical factor in the maintenance of cell-wall integrity, Presentation Description No description available. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Type of hyperlipidemia Primary hyperlipidemia Secondary hyperlipidemia. Hyperuricemia and gout Niacin inhibits tubular secretion of uric acid Impaired glucose tolerance Hepatotoxicity. Therapeutic uses Antihyperlipidemuc the most effective in reduction TGs – combined hyperlipidemia type III if statins are contraindicated.
Mechanism of action of statins PowerPoint Presentation: Emollients Cicatrizants Antipruritics Antipsoriatics Medicated dressings. Classifictaion view content sources and attributions, please refer to our editorial policy.
List of Antihyperlipidemic agents – Generics Only –
Alpha- tocopherol acetate vitamin E Omega-3 marine triglycerides Maxepa Orlistat. Lipid disorders Disorders of lipid metabolism are manifest by elevation of the plasma concentrations of the various lipid and lipoprotein fractions total and LDL cholesterol, VLDL, triglycerides, chylomicrons and they result in cardiovascular disease and atherosclerosis deposition of fats at walls of arteries, forming plaque.
By reducing the LDL cholesterol, they can antihypsrlipidemic both the primary and secondary symptoms of coronary heart disease. In order to view it, please contact the author of the presentation. Contraindication Where hepatic or renal function is severely impaired but gemfibrozil has been used in uraemic and nephrotic patients without aggravating deterioration in kidney function pregnant or lactating women.
Anti Hyperlipidemic Drugs |authorSTREAM
Excretion takes place through the bile and feces some urinary elimination also occurs. Tetracycline, warfarindigoxinthiazide diuretics, phenobarbitone and thyroid hormones should be taken 1 h-2h before or 4 h-6h after colestyramine to avoid impairment of their absorption Because the drug binds anions Niacin nicotinic acid: Decongestants Bronchodilators Cough medicines H 1 antagonists.
Plasma creatine kinase levels should be determined regularly. A formulation of ezetimibe and simvastatin has been shown to lower LDL levels more effectively than the statin alone. Subscribe to free Drugs. Their half-lives range from 1.
Start Free Trial No credit card required. For example, some may lower the “bad cholesterol” low density lipoprotein LDL more so than others, while others may preferentially increase high density antiuyperlipidemic HDL”the good cholesterol”. This page was last edited on 23 Februaryat Anti- hyperlipidemic drugs are mainly classified into 5 types: Adverse effect of statins: These drugs drugd contraindicated during pregnancy and in nursing mothers.
Niacin nicotinic acid Mechanism of action: Pravastatin and fluvastatin are almost completely absorbed after oral administration.
Available for Android and iOS devices. Adverse effect of statins Transient, and minor abnormality of liver function tests Myopathy and rhabdomyolysis disintegration or dissolution of muscle and elevation of muscle enzymes creatine hosphokinaseCPK: Colesevelam has fewer gastrointestinal side effects and not Impaired absorptions.
Contraindication Where hepatic or renal function is severely impaired but gemfibrozil has been used in uraemic and nephrotic patients without aggravating deterioration in kidney function pregnant or lactating women PowerPoint Presentation: Mechanism of action of statins: Describe the cholesterol biosynthetic pathway and its significance.
Niacin is administered orally. Niacin is also used to treat other severe hypercholesterolemiasoften in combination with other antihyperlipidemic agents. Orlistata weight-reducing agent, it is pancreatic lipase inhibitor lowers the Glycaemia of diabetes mellitus to a degree that Accords with the weight loss, and improves Hyperlipidaemia There is a risk of steatorrhoea and alabsorption of Fat-soluble vitamins A, D and E. By clicking Subscribe, I agree to the Drugs.
Niacin lowers plasma levels of both cholesterol and triacylglycerol. Niacin nicotinic acid PowerPoint Presentation: Antidotes Contrast media Cclassification Dressings Senotherapeutics. The most severe hyperlipidaemias usually occur In patients with concurrent conditions, e.
In patients with renal insufficiency In patients taking drugs such as cyclosporine, itraconazoleerythromycin, gemfibrozilor niacin.